Is This Melatonin & Tylenol Combo Killing You?

We report a case of death due to otc sleep aid toxicity, in which there were elevated concentrations of both dph and melatonin. Tylenol pm (acetaminophen / diphenhydramine) and melatonin using diphenhydramine together with melatonin may increase side effects such as dizziness,. When a medication works right, it boosts your health or helps you feel better. But a drug can bring on problems if it doesn't mix well with something else you put into your body, like another. Unlike with many sleep medications, with melatonin you are unlikely to become dependent on it, have less response to it after.