Dr. Edden’s research is concerned with both the development of new MRS methods and the application of existing methods to investigate the brain. One technical area of my research is the behaviour of coupled spin systems (such as lactate, citrate, GABA and Glx) during localised spectroscopy experiments; in particular, considering the interplay between finite-bandwidth slice-selective pulses and the chemical shift difference between coupled spins. The result of coupling evolution can change significantly across selected volumes, resulting in loss of signal intensity.